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The present article summarizes our present knowledge which results from studies, all carried out on women with breast cancer we review the side effects on the female genital apparatus, the ovarian and non ovarian endocrine side effects, the effects on cardio vascular and thromboembolic risks, on bone metabolism and on ocular and hepatic side effects <a href=https://nolvadex.one/>tamoxifen bodybuilding</a> Novel approaches for molecular targeted therapy of breast cancer interfering with PI3K AKT mTOR signaling